7-Boc-5,6,7,8-四氢-1,2,4-三唑并[4,3-a]吡嗪合成路线 （共 3 条）
反应条件
triethylamine in dichloromethane T=25°C;
参考文献
GRUeNENTHAL GMBH
Patent: WO2009/90055 A1, 2009 ;
Location in patent: Page/Page column 140; 141 ;
WO 2009/090055 A1
反应条件
N-bromosuccinmide; sodium hydrogencarbonate in chloroform T=0 - 20°C; 16 h;
参考文献
MERCK and CO., INC.
Patent: WO2004/58266 A1, 2004 ;
Location in patent: Page/Page column 80 ;
WO 2004/058266 A1
反应条件
1: 7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[3,4-a]pyrazine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.25 h; 2: formic acid ethyl ester in tetrahydrofuran; hexane T=-78°C; 0.25 h;
参考文献
GRUeNENTHAL GMBH
Patent: WO2009/90055 A1, 2009 ;
Location in patent: Page/Page column 141; 142 ;
WO 2009/090055 A1
