7-Boc-3-溴-5,6,7,8-四氢-1,2,4-三唑并[4,3-a]吡嗪合成路线 （共 3 条）
反应条件
N-bromosuccinmide; sodium hydrogencarbonate in chloroform T=0 - 20°C; 16 h;
参考文献
WO2004/58266 A1, ;
Page/Page column 80 ;
WO 2004/058266 A1
反应条件
trifluoroacetic acid in dichloromethane T=0 - 20°C; 16 h;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED; HOELDER, Swen; BLAGG, Julian; CHEUNG, Jack; ATRASH, Butrus; SHELDRAKE, Peter
Patent: WO2014/37751 A1, 2014 ;
Location in patent: Paragraph 00459-00461 ;
反应条件
in methanol
T=65°C; 24 h;
参考文献
MERCK and CO., INC.
Patent: WO2004/58266 A1, 2004 ;
Location in patent: Page/Page column 80 ;
WO 2004/058266 A1
