1-二苯甲基-3-羟甲基-氮杂环丁烷合成路线 （共 9 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 3.66667 h; 2: With sodium hydroxide; water in tetrahydrofuran T=0°C; 0.333333 h;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP1961750 A1, 2008 ;
Location in patent: Page/Page column 78-79 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 16 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2006/72353 A1, 2006 ;
Location in patent: Page/Page column 53 ;
反应条件
1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 2: water; N,N-dimethyl-formamide / 90 °C 3: sulfuric acid / 2 h / 90 °C 4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 20 p. 6031 - 6035
反应条件
1: water; N,N-dimethyl-formamide / 90 °C 2: sulfuric acid / 2 h / 90 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 20 p. 6031 - 6035
反应条件
1: sulfuric acid / 2 h / 90 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 20 p. 6031 - 6035
反应条件
1: ethanol / 144 h / 20 °C / Reflux 2: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 3: water; N,N-dimethyl-formamide / 90 °C 4: sulfuric acid / 2 h / 90 °C 5: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 20 p. 6031 - 6035
反应条件
1: With hydrogen; palladium hydroxide on carbon in methanol P=3000.3 Torr; 2: With hydrogenchloride in methanol; ethyl acetate
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2119706 A1, 2009 ;
Location in patent: Page/Page column 48-49 ;
EP 2119706 A1
反应条件
1: 1-diphenylmethyl-3-hydroxymethylazetidine With hydrogenchloride; hydrogen; Pearlman's catalist in methanol T=20°C; 17.5 h; Inert atmosphere; 2: di-tert-butyl dicarbonate in acetonitrile T=20°C; 16 h;
参考文献
US2010/261701 A1, ;
Page/Page column 145 ;
反应条件
triethylamine in tetrahydrofuran T=20°C; 2 h;
参考文献
Chambers, Mark Stuart; Curtis, Neil Roy; MacLeod, Angus Murray; Maxey, Robert James; Szekeres, Helen Jane
Patent: US2005/101586 A1, 2005 ;
Location in patent: Page/Page column 6 ;
