反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 2.1: thionyl chloride / dichloromethane / 20 °C 3.1: ethanol / 3 h / |Reflux 4.1: 1-chloroethyl chlorocarbonate / 1,2-dichloro-ethane / 48 h / |Reflux 4.2: 1 h / |Reflux View Scheme
参考文献
CEPHALON, INC.; CANCER RESEARCH TECHNOLOGY LIMITED; BRESLIN, Henry, J.; DORSEY, Bruce, D.; DUGAN, Benjamin, J.; FOWLER, Katherine, M.; HUDKINS, Robert, L.; MESAROS, Eugen, F.; MONCK, Nathaniel, JT; MORRIS, Emma, L.; OLOWOYE, Ikeoluwa; OTT, Gregory, R.; PAVE, Gregoire, A.; ROFFEY, Jonathan, R. A.; SOUDY, Christelle, N.; TAO, Ming; ZIFICSAK, Craig, A.; ZULLI, Allison, L.
Patent: WO2014/52699 A1, 2014 ;