2-氟-6-羟基苯甲酸甲酯合成路线 （共 3 条）
反应条件
sulfuric acid T=60°C; 45 h;
参考文献
PFIZER INC.; NOGUCHI, Hirohide; WAIZUMI, Nobuaki
Patent: WO2011/101774 A1, 2011 ;
Location in patent: Page/Page column 25-26 ;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 7 p. 2119 - 2124
反应条件
1.1: hydroxylammonium sulphate; potassium carbonate / water; methanol / 21.5 h / 15 - 35 °C / Industry scale
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 7 h / 25 - 60 °C
2.2: 1.25 h / 15 - 20 °C / pH 1
View Scheme
参考文献
PFIZER INC.; NOGUCHI, Hirohide; WAIZUMI, Nobuaki
Patent: WO2011/101774 A1, 2011 ;
