2-氨基-4-甲氧基-5-嘧啶羧酸合成路线 （共 22 条）
反应条件
sodium hydroxide in methanol; water
T=65°C; 1 h;
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 62 percent / pyridine / 2 h / Heating
2: 81 percent / phosphorus oxychloride / 2 h / 60 °C
3: 95 percent / sodium / Ambient temperature
4: 77 percent / NaOH / methanol; H2O / 1 h / 65 °C
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 81 percent / phosphorus oxychloride / 2 h / 60 °C
2: 95 percent / sodium / Ambient temperature
3: 77 percent / NaOH / methanol; H2O / 1 h / 65 °C
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 95 percent / sodium / Ambient temperature
2: 77 percent / NaOH / methanol; H2O / 1 h / 65 °C
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
chloroformic acid ethyl ester; triethylamine
1.) DMF, 0 deg C, 30 min, 2.) room temp.; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
chloroformic acid ethyl ester; triethylamine
1.) DMF, 0 deg C, 30 min, 2.) room temp.; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
chloroformic acid ethyl ester; triethylamine
1.) DMF, 0 deg C, 30 min, 2.) room temp.; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
chloroformic acid ethyl ester; triethylamine
1.) DMF, 0 deg C, 30 min, 2.) room temp.; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
chloroformic acid ethyl ester; triethylamine
1.) DMF, 0 deg C, 30 min, 2.) room temp.; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
chloroformic acid ethyl ester; triethylamine
1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
