1-甲基-5-氧代脯氨酸合成路线 （共 10 条）
反应条件
phosphorus pentachloride in toluene T=80°C; 4 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Effenberger, Franz; Mueller, Wolfgang; Isak, Heinz
Chemische Berichte, 1987 , vol. 120, p. 45 - 54
反应条件
phosphorus pentachloride 1.) 5 h, 60 deg C, 2.) 0.5 h, 75 deg C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Effenberger, Franz; Mueller, Wolfgang; Isak, Heinz
Chemische Berichte, 1987 , vol. 120, p. 45 - 54
反应条件
phosphorus pentachloride in chlorobenzene 1.) 11 h, 80 deg C, 2.) 1.5 h, 130 deg C;
参考文献
Effenberger, Franz; Mueller, Wolfgang; Isak, Heinz
Chemische Berichte, 1987 , vol. 120, p. 45 - 54
反应条件
phosphorus pentachloride in toluene T=80°C; 4 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Effenberger, Franz; Mueller, Wolfgang; Isak, Heinz
Chemische Berichte, 1987 , vol. 120, p. 45 - 54
反应条件
phosphorus pentachloride 1.) 5 h, 60 deg C, 2.) 0.5 h, 75 deg C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Effenberger, Franz; Mueller, Wolfgang; Isak, Heinz
Chemische Berichte, 1987 , vol. 120, p. 45 - 54
反应条件
1: With sodium hydroxide; water in ethanol; isopropyl alcohol
T=0°C; 4 h;
2: With hydrogenchloride in water
pH=1; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: US2008/9541 A1, 2008 ;
Location in patent: Page/Page column 37 ;
参考文献
You, Zhengqing; Lee, Henry
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 1 p. 37 - 54
反应条件
in water
T=140°C; 0.5 h; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: US2008/9541 A1, 2008 ;
Location in patent: Page/Page column 14; 28 ;
参考文献
Hardegger; Ott
Helvetica Chimica Acta, 1955 , vol. 38, p. 312,317
反应条件
methanesulfonic acid; phosphorus pentoxide in neat (no solvent)
T=100°C; 1 h;
参考文献
Rigo; Fasseur; Cherepy; Couturier
Tetrahedron Letters, 1989 , vol. 30, # 50 p. 7057 - 7060
