6-羟基-2-(甲基氨基)-己腈合成路线 （共 3 条）
反应条件
1: With sodium cyanide; sulfuric acid in water
T=20 - 35°C; 1 h;
2: With sodium cyanide; methylamine in water
T=0 - 20°C; pH=6 - 7; 36 h;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
Patent: WO2004/58756 A1, 2004 ;
Location in patent: Page 60 ;
反应条件
in water
T=20°C; 36 h;
参考文献
MERCK and CO., INC.; BANYU PHARMACEUTICAL CO., LTD.
Patent: WO2005/61501 A2, 2005 ;
Location in patent: Page/Page column 62 ;
反应条件
in isopropanol acetate
T=30 - 35°C; 2 h;
参考文献
MERCK and CO., INC.; BANYU PHARMACEUTICAL CO., LTD.
Patent: WO2005/61501 A2, 2005 ;
Location in patent: Page/Page column 70 ;
