2-(2-咪唑-1-乙基)-异吲哚-1,3-二酮合成路线 （共 7 条）
反应条件
hydrogenchloride; hydrazine hydrate 1.) EtOH, reflux, 8 h, 2.) EtOH, reflux, 6 h; Multistep reaction;
参考文献
Wright Jr.; Press; Chan; Marsico; Haug; Lucas; Tauber; Tomcufcik
Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 523 - 530
反应条件
hydrazine in ethanol 16 h; Heating;
参考文献
Bergstrom, Carl P.; Sloan, Charles P.; Lau, Wai-Yu; Smith, David W.; Zheng, Ming; Hansel, Steven B.; Polson, Craig T.; Corsa, Jason A.; Barten, Donna M.; Felsenstein, Kevin M.; Roberts, Susan B.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 464 - 468
反应条件
hydrogenchloride; hydrazine hydrate 1.) EtOH, reflux, 8 h, 2.) EtOH, reflux, 6 h; Multistep reaction;
参考文献
Wright Jr.; Press; Chan; Marsico; Haug; Lucas; Tauber; Tomcufcik
Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 523 - 530
反应条件
1: 1H-imidazole With sodium hydride in N,N-dimethyl-formamide
2: N-(2-bromo-ethyl)-phthalimide in N,N-dimethyl-formamide
T=100°C; 8 h;
参考文献
Popkov; Skvortsova
Russian Chemical Bulletin, 2006 , vol. 55, # 10 p. 1848 - 1851
反应条件
in isopropyl alcohol; toluene
参考文献
American Cyanamid Company
Patent: US4489089 A1, 1984 ;
反应条件
in N,N-dimethyl-formamide
参考文献
Press, J. B.; Haug, M. F.; Wright, W. B.
Synthetic Communications, 1985 , vol. 15, # 9 p. 837 - 842
反应条件
silver-compound of 1H-imidazole; xylene
参考文献
Lur'e et al.
Zhurnal Obshchei Khimii, 1939 , vol. 9, p. 1933,1936
Chem. Zentralbl., 1940 , vol. 111, # I p. 2466
