1: 80 percent / lipase Amano P / H2O; diisopropyl ether / 22 h / 33 °C 2: 100 percent / triphenylphosphane; imidazole; iodine / tetrahydrofuran / 0.5 h / 20 °C 3: 92 percent / NaBH4 / dimethylsulfoxide / 1 h / 20 °C View Scheme

1: 80 percent / lipase Amano P / H2O; diisopropyl ether / 22 h / 33 °C 2: 100 percent / triphenylphosphane; imidazole; iodine / tetrahydrofuran / 0.5 h / 20 °C 3: 92 percent / NaBH4 / dimethylsulfoxide / 1 h / 20 °C 4: 89 percent / potassium carbonate / methanol / 0.42 h / 20 °C View Scheme