(S)-5-溴甲基-2-吡咯烷酮合成路线 （共 6 条）
反应条件
carbon tetrabromide; triphenylphosphine in acetonitrile T=25°C; 70 h;
参考文献
TETRAPHASE PHARMACEUTICALS, INC.; CHEN, Chi-Li; CLARK, Roger, B.; DENG, Yonghong; PLAMONDON, Louis; SUN, Cuixiang; XIAO, Xiao-Yi
Patent: WO2012/21712 A1, 2012 ;
Location in patent: Page/Page column 162 ;
反应条件
1: 78 percent / NaBH4 / ethanol / 2 h / Ambient temperature 2: 72.8 percent / CBr4, Ph3P / acetonitrile / Ambient temperature View Scheme
参考文献
Journal of the American Chemical Society, , vol. 112, # 2 p. 838 - 845
反应条件
1: 89.1 percent / thionyl chloride / 1.5 h / Ambient temperature 2: 78 percent / NaBH4 / ethanol / 2 h / Ambient temperature 3: 72.8 percent / CBr4, Ph3P / acetonitrile / Ambient temperature View Scheme
参考文献
Journal of the American Chemical Society, , vol. 112, # 2 p. 838 - 845
反应条件
1: 84 percent / SOCl2 / ethanol / 1) 0 deg C; 2) 1 h, room temp., then 0.5 h reflux 2: 1) NaBH4, LiCl / 1) diglyme, THF, 20 min.; 2) 9h, room temp., THF 3: 74 percent / Ph3P, CBr4 / acetonitrile / 1) 0 deg C, 15 min; 2) 12 h, room temp. View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 5 p. 815 - 818
反应条件
1: 1) NaBH4, LiCl / 1) diglyme, THF, 20 min.; 2) 9h, room temp., THF 2: 74 percent / Ph3P, CBr4 / acetonitrile / 1) 0 deg C, 15 min; 2) 12 h, room temp. View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 5 p. 815 - 818
反应条件
sodium azide; 18-crown-6 ether in acetonitrile T=85°C; 16 h;
参考文献
Gawell, Lars; Stroem, Peter; Hoegberg, Thomas
Acta Chemica Scandinavica, 1992 , vol. 46, # 10 p. 981 - 984
