1-Boc-4-甲基哌啶-4-甲酸甲酯合成路线 （共 8 条）
反应条件
lithium diisopropyl amide in tetrahydrofuran T=-78 - 23°C; 25 h;
参考文献
Renslo, Adam R.; Atuegbu, Andy; Herradura, Prudencio; Jaishankar, Priyadarshini; Ji, Mingzhe; Leach, Karen L.; Huband, Michael D.; Dermyer, Michael R.; Wu, Luping; Vara Prasad; Gordeev, Mikhail F.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 18 p. 5036 - 5040
反应条件
1: N-t-butoxycarbonyl-4-methylpiperidine-4-carboxylic acid With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78 - 0°C; 3.5 h; 2: methyl iodide in tetrahydrofuran; hexane T=-78 - 20°C; 2 h;
参考文献
WO2006/73361 A1, ;
Page/Page column 162 ;
WO 2006/073361 A1
反应条件
1: 1-(t-butoxycarbonyl)-4-(carboxy)piperidine With lithium diisopropyl amide in tetrahydrofuran; cyclohexane T=-78 - 0°C; 0.5 h; 2: methyl iodide in tetrahydrofuran; cyclohexane T=20°C; 18 h;
参考文献
US2007/72833 A1, ;
Page/Page column 29 ;
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / |Inert atmosphere 2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere 2.2: -78 - 20 °C / |Inert atmosphere View Scheme
参考文献
WO2013/19621 A1, ;
WO 2013/019621 A1
反应条件
1: lithium hydroxide hydrate / tetrahydrofuran; water / 45 °C 2: triethylamine; diphenyl phosphoryl azide / toluene / 20 - 80 °C / |Inert atmosphere 3: hydrogenchloride / 1,4-dioxane / 50 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19621 A1, 2013 ;
WO 2013/019621 A1
反应条件
1: lithium hydroxide hydrate / tetrahydrofuran; water / 45 °C 2: triethylamine; diphenyl phosphoryl azide / toluene / 20 - 80 °C / |Inert atmosphere View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19621 A1, 2013 ;
WO 2013/019621 A1
反应条件
lithium hydroxide hydrate in tetrahydrofuran; water T=45°C;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19621 A1, 2013 ;
Location in patent: Page/Page column 57; 58 ;
WO 2013/019621 A1
反应条件
hydrogenchloride in tetrahydrofuran; 1,4-dioxane
T=20°C;
参考文献
ASTRAZENECA AB
Patent: WO2007/8140 A1, 2007 ;
Location in patent: Page/Page column 107-108 ;
WO 2007/008140 A1
