反应条件
1: 91 percent / pyridine hydrochloride / 2 h / 180 °C
2: K2CO3 / dimethylformamide / 1.) 60 deg C, 2 h, 2.) from 60 deg C to RT, overnight
3: 63 percent / 5percent aq. NaOH / ethanol / 0.5 h / Heating
View Scheme
参考文献
Shutske, Gregory M.; Setescak, Linda L.; Allen, Richard C.; Davis, Larry; Effland, Richard C.; et al.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 36 - 44
