反应条件
1: pyridine hydrochloride / 2 h / 180 °C
2: K2CO3 / dimethylformamide / 1.) 60 deg C, 2 h, 2.) from 60 deg C to RT, overnight
3: aq. NaOH / dimethylformamide / 1.5 h / 90 °C
View Scheme
参考文献
Shutske, Gregory M.; Setescak, Linda L.; Allen, Richard C.; Davis, Larry; Effland, Richard C.; et al.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 36 - 44
