3,5-双三氟甲基苯甲酸合成路线 （共 16 条）
反应条件
n-butyllithium in diethyl ether T=-75°C;
参考文献
Leazer Jr., Johnnie L.; Cvetovich, Raymond; Tsay, Fuh-Rong; Dolling, Ulf; Vickery, Thomas; Bachert, Donald
Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3695 - 3698
反应条件
water in diethyl ether
参考文献
MITSUBISHI GAS CHEMICAL COMPANY, INC.
Patent: EP1500641 A1, 2005 ;
Location in patent: Page 9 ;
反应条件
N,N,N',N'',N''-pentamethyldiethylenetriamine; sec.-butyllithium in tetrahydrofuran T=-75°C; 2 h;
参考文献
Chemistry - A European Journal, , vol. 4, # 7 p. 1281 - 1286
反应条件
1: With trifluorormethanesulfonic acid in chloroform 4 h; Inert atmosphere; 2: With water in chloroform Inert atmosphere;
参考文献
Kethe, Anila; Tracy, Adam F.; Klumpp, Douglas A.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 12 p. 4545 - 4549
反应条件
1.1: 94 percent / sulfuric acid; 1,3-dibromo-5,5-dimethylhydantoin / acetic acid / 4 h / 45 °C 2.1: i-PrMgCl / tetrahydrofuran / 1 h / -10 °C 2.2: 94 percent / tetrahydrofuran / 1 h / -45 °C / 1034.3 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 9 p. 3695 - 3698
反应条件
2,2,6,6-tetramethyl-piperidine; n-butyllithium 1.) THF, -78 deg C, 1.5 h, 2.) THF; Yield givenMultistep reaction. Yields of byproduct given;
参考文献
Tetrahedron, , vol. 55, # 4 p. 909 - 918
反应条件
lithium aluminium tetrahydride in diethyl ether 3 h; Heating;
参考文献
Blackburn, Christopher; Childs, Ronald F.; Cremer, Dieter; Gauss, Juergen
Journal of the American Chemical Society, 1985 , vol. 107, # 8 p. 2442 - 2448
反应条件
1: (COCl)2; DMF / CH2Cl2 2: diethyl ether / 0 °C 3: aq. Ag2O / dioxane 4: (COCl)2; DMF / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 15 p. 1723 - 1727
反应条件
1: SOCl2 2: 83 percent Chromat. / HCOONH4 / Ru3(CO)12 / dioxane / 20 h / 160 °C View Scheme
参考文献
Chatani; Tatamidani; Ie; Kakiuchi; Murai
Journal of the American Chemical Society, 2001 , vol. 123, # 20 p. 4849 - 4850
反应条件
(i) SOCl2, (ii) Li<AlH(OtBu)3>, diglyme; Multistep reaction;
参考文献
Blackburn, Christopher; Childs, Ronald F.; Cremer, Dieter; Gauss, Juergen
Journal of the American Chemical Society, 1985 , vol. 107, # 8 p. 2442 - 2448
