N-(2-氯乙基)吡咯烷盐酸盐合成路线 （共 42 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 3 h;
参考文献
Pan, Xiaoyan; Dong, Jinyun; Gao, Hongping; Wang, Fang; Zhang, Yanmin; Wang, Sicen; Zhang, Jie
Chemical Biology and Drug Design, 2014 , vol. 83, # 5 p. 592 - 599
反应条件
potassium carbonate; xylene
参考文献
Kaye et al.
Journal of Organic Chemistry, 1951 , vol. 16, p. 1421,1424
反应条件
tetrabutylammomium bromide; water; sodium hydroxide in toluene T=90°C; 18 h;
参考文献
XENTION LIMITED; MADGE, David; CHAN, Fiona; JOHN, Derek Edward; EDWARDS, Simon D.; BLUNT, Richard; HARTZOULAKIS, Basil; BROWN, Lindsay
Patent: WO2013/72694 A1, 2013 ;
Location in patent: Page/Page column 131; 132 ;
反应条件
ammonium hydroxide 0.5 h;
参考文献
De Costa; Radesca; Di Paolo; Bowen
Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 38 - 47
反应条件
potassium carbonate in acetone 30 h; Heating;
参考文献
Saeed; Sharma; Durani; Jain; Kapil
Journal of Medicinal Chemistry, 1990 , vol. 33, # 12 p. 3210 - 3216
反应条件
caesium carbonate in acetonitrile T=20°C; 18 h;
参考文献
US2010/273796 A1, ;
Page/Page column 20-21 ;
反应条件
sodium ethanolate in ethanol T=78°C; 60 h; Inert atmosphere; Reagent/catalyst;
参考文献
Ace, Karl W.; Armitage, Mark A.; Bellingham, Richard K.; Blackler, Paul D.; Ennis, David S.; Hussain, Nigel; Lathbury, David C.; Morgan, David O.; O'Connor, Noah; Oakes, Graham H.; Passey, Stephen C.; Powling, Laurence C.
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 479 - 490
参考文献
Daniels, AnTawan; Ayala, Erika; Chen, Weibin; Coop, Andrew; Matsumoto, Rae R.
European Journal of Pharmacology, 2006 , vol. 542, # 1-3 p. 61 - 68
反应条件
1: 64 percent / methanol / 96 h / Ambient temperature 2: N,N'-dicyclohexylcarbodiimide (DCC) / CH2Cl2 / 0.5 h / Ambient temperature 3: AlH3 / tetrahydrofuran / 0.08 h / Ambient temperature View Scheme
参考文献
De Costa; Radesca; Di Paolo; Bowen
Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 38 - 47
反应条件
1: 65 percent / H2O / 0.5 h 2: N,N'-dicyclohexylcarbodiimide (DCC) / CH2Cl2 / 0.5 h / Ambient temperature 3: AlH3 / tetrahydrofuran / 0.08 h / Ambient temperature View Scheme
参考文献
De Costa; Radesca; Di Paolo; Bowen
Journal of Medicinal Chemistry, 1992 , vol. 35, # 1 p. 38 - 47
