苯基-(2-吡啶基)乙酰胺合成路线 （共 6 条）
反应条件
1: With sulfuric acid T=10 - 20°C; 16 h; 2: With sodium hydroxide in water T=10 - 30°C; pH=12;
参考文献
Celgene Corporation
Patent: US6359139 B1, 2002 ;
Location in patent: Example 1 ;
反应条件
sodium hydroxide in water
参考文献
Celgene Corporation
Patent: US5936091 A1, 1999 ;
反应条件
1: NaNH2; toluene 2: aqueous H2SO4 View Scheme
参考文献
Helvetica Chimica Acta, , vol. 27, p. 1748,1753
Archiv der Pharmazie (Weinheim, Germany), , vol. 286, p. 433,436
反应条件
1: NaNH2; toluene 2: aqueous H2SO4 View Scheme
参考文献
Helvetica Chimica Acta, , vol. 27, p. 1748,1753
Archiv der Pharmazie (Weinheim, Germany), , vol. 286, p. 433,436
反应条件
1: H2 / 5percent Pt/C / acetic acid / 10 h / 1551.4 - 2068.6 Torr 2: 1.) 6N HCl, 2.) 50percent KOH / 1.) reflux, 6 h, 2.) reflux, 4 d View Scheme
参考文献
Deutsch, Howard M.; Shi, Qing; Gruszecka-Kowalik, Ewa; Schwer, Margaret M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1201 - 1209
反应条件
hydrogen; acetic acid; 5 rhodium-on-charcoal T=50 - 55°C; P=11251.1 Torr; 5 - 6 h;
参考文献
CLARIANT LIFE SCIENCE MOLECULES (ITALIA) S.P.A.
Patent: WO2006/64052 A1, 2006 ;
Location in patent: Page/Page column 4 ;
