5-溴-2,3-二甲氧基苯甲酸合成路线 （共 20 条）
反应条件
1: SOCl2; DMF / toluene / 2 h / 80 °C 2: 3.18 g / CH2Cl2 / 20 °C View Scheme
参考文献
De Paulis; Smith
Synthetic Communications, 1991 , vol. 21, # 8-9 p. 1091 - 1095
反应条件
1: 95 percent / thionyl chloride / benzene / Heating 2: 100 percent / Et3N / CH2Cl2 / 20 °C 3: 88 percent / POCl3 / benzene / 10 h / Heating View Scheme
参考文献
Huang, Yunsheng; Luedtke, Robert R.; Freeman, Rebekah A.; Wu, Li; Mach, Robert H.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 12 p. 3113 - 3122
反应条件
potassium permanganate in water
5 h; Heating;
参考文献
Daukshas, V. K.; Martinkus, R. S.; Kuleshyus, V. A.; Shtel'bene, V. P.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 458 - 463
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 3 p. 522 - 528
反应条件
sodium hydroxide in methanol; water
Heating;
参考文献
Mach, Robert H.; Hammond, Philip S.; Huang, Yunsheng; Yang, Biao; Xu, Yueping; Cheney, Jason T.; Freeman, Rebekah; Luedtke, Robert R.
Medicinal Chemistry Research, 1999 , vol. 9, # 6 p. 355 - 373
反应条件
potassium carbonate in acetone
Heating;
参考文献
Huang, Yunsheng; Luedtke, Robert R.; Freeman, Rebekah A.; Wu, Li; Mach, Robert H.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 12 p. 3113 - 3122
Title/Abstract View citing articles Show Details
Tiwari, Shashi B.; Kohli
Medicinal Chemistry Research, 2008 , vol. 17, # 2-7 p. 386 - 398
反应条件
potassium permanganate in water
10 h; Heating;
参考文献
Daukshas, V. K.; Martinkus, R. S.; Kuleshyus, V. A.; Shtel'bene, V. P.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 458 - 463
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 3 p. 522 - 528
反应条件
1: 93 percent / K2CO3 / butan-2-one / 2 h / 80 °C
2: 72 percent / KMnO4; K2HPO4*3H2O / 2-methyl-propan-2-ol; H2O / 0.5 h
View Scheme
参考文献
Sandell, Johan; Langer, Oliver; Larsen, Peter; Dolle, Frederic; Vaufrey, Francoise; Demphel, Stephane; Crouzel, Christian; Halldin, Christer
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 4 p. 331 - 338
反应条件
1: 88 percent / Br2 / acetic acid / 20 °C
2: 86 percent / potassium carbonate / acetone / Heating
View Scheme
参考文献
Huang, Yunsheng; Luedtke, Robert R.; Freeman, Rebekah A.; Wu, Li; Mach, Robert H.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 12 p. 3113 - 3122
反应条件
1: 85 percent / Br2, KBr, acetic acid / 0.33 h / 110 °C
2: 91 percent / K2CO3 / acetone / 16 h / Heating
3: 75 percent / AgNO3, 1N aq. NaOH / methanol / 5 h / 85 °C
View Scheme
参考文献
De Paulis; Smith
Synthetic Communications, 1991 , vol. 21, # 8-9 p. 1091 - 1095
反应条件
permanganate(VII) ion
T=60 - 70°C;
参考文献
Rubenstein
Journal of the Chemical Society, 1926 , p. 650
