7-羟基-4,6-二甲基壬烷-3-酮合成路线 （共 59 条）
反应条件
1: 96.7 percent / H2 / 10percent Pd-C / ethanol 2: pyridine / 0 °C / several hours 3: NaI, NaHCO3 / acetone / Heating; several hours 4: 1) LDA, / 1) THF-hexane-HMPA, -55 deg C, 30 min, 2) THF-hexane-HMPA, -60 to -5 deg C, 3 h 5: 37 percent / AcOH, H2O / tetrahydrofuran / 24 h / 40 °C View Scheme
参考文献
Tetrahedron, , vol. 41, # 16 p. 3423 - 3428
反应条件
1: TsOH, MeOH / 0.5 h / Ambient temperature 2: 52 percent / Ph3P, EtO2CN=NCO2Et / tetrahydrofuran / 24 h / Ambient temperature 3: 95 percent / N KOH aq / tetrahydrofuran; ethanol / 1 h / Ambient temperature 4: imidazole / dimethylformamide / Ambient temperature; several hours 5: 96.7 percent / H2 / 10percent Pd-C / ethanol 6: pyridine / 0 °C / several hours 7: NaI, NaHCO3 / acetone / Heating; several hours 8: 1) LDA, / 1) THF-hexane-HMPA, -55 deg C, 30 min, 2) THF-hexane-HMPA, -60 to -5 deg C, 3 h 9: 37 percent / AcOH, H2O / tetrahydrofuran / 24 h / 40 °C View Scheme
参考文献
Tetrahedron, , vol. 41, # 16 p. 3423 - 3428
反应条件
1: TsOH / benzene / Heating 2: iPr2NH2, 2.5M n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -50 deg C, 10 min, then 0 deg C, 45 min 3: AcOH, 1M HCl / tetrahydrofuran; H2O / 48 h / 50 - 55 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 9 p. 2703 - 2714
反应条件
1: 47 percent / benzene / 72 h / Ambient temperature 2: n-BuLi / tetrahydrofuran; hexane / 0.08 h / 0 °C 3: tetrahydrofuran / 2 h / 0 °C 4: formic acid, Et3N / Pd2(dba)3CHCl3-P(OMe)3 / dioxane / 2 h / Ambient temperature; var. phosphorus ligands; var. times; var. concentrations of formic acid 5: 83 percent / H2 / 5percent Pd/C / methanol / 24 h / Ambient temperature 6: 11 percent / p-TsOH / tetrahydrofuran; H2O / 5 h / 50 °C View Scheme
参考文献
Tetrahedron, , vol. 47, # 18-19 p. 2991 - 2998
反应条件
1: tetrahydrofuran / 2 h / 0 °C 2: formic acid, Et3N / Pd2(dba)3CHCl3-P(OMe)3 / dioxane / 2 h / Ambient temperature; var. phosphorus ligands; var. times; var. concentrations of formic acid 3: 83 percent / H2 / 5percent Pd/C / methanol / 24 h / Ambient temperature 4: 11 percent / p-TsOH / tetrahydrofuran; H2O / 5 h / 50 °C View Scheme
参考文献
Tetrahedron, , vol. 47, # 18-19 p. 2991 - 2998
反应条件
1: 83 percent / H2 / 5percent Pd/C / methanol / 24 h / Ambient temperature 2: 11 percent / p-TsOH / tetrahydrofuran; H2O / 5 h / 50 °C View Scheme
参考文献
Tetrahedron, , vol. 47, # 18-19 p. 2991 - 2998
反应条件
1: tetrahydrofuran / 2 h / 0 °C 2: formic acid, Et3N / Pd2(dba)3CHCl3-P(OMe)3 / dioxane / 2 h / Ambient temperature; var. phosphorus ligands; var. times; var. concentrations of formic acid 3: 83 percent / H2 / 5percent Pd/C / methanol / 24 h / Ambient temperature 4: 11 percent / p-TsOH / tetrahydrofuran; H2O / 5 h / 50 °C View Scheme
参考文献
Tetrahedron, , vol. 47, # 18-19 p. 2991 - 2998
反应条件
1: n-BuLi / tetrahydrofuran; hexane / 0.08 h / 0 °C 2: tetrahydrofuran / 2 h / 0 °C 3: formic acid, Et3N / Pd2(dba)3CHCl3-P(OMe)3 / dioxane / 2 h / Ambient temperature; var. phosphorus ligands; var. times; var. concentrations of formic acid 4: 83 percent / H2 / 5percent Pd/C / methanol / 24 h / Ambient temperature 5: 11 percent / p-TsOH / tetrahydrofuran; H2O / 5 h / 50 °C View Scheme
参考文献
Tetrahedron, , vol. 47, # 18-19 p. 2991 - 2998
反应条件
1: tetrahydrofuran 2: HCO2H, Et3N, trimethyl phosphite / Pd2(dba)3CHCl3 (5 molpercent) / dioxane / 3 h / Ambient temperature 3: H2 / Pd/C / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 33 p. 4757 - 4758
反应条件
hydrogen; palladium on activated charcoal in methanol Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 31, # 33 p. 4757 - 4758
