7-羟基-4,6-二甲基壬烷-3-酮合成路线 （共 59 条）
反应条件
1: ethyl bromide With lithium in diethyl ether 2: (3R,5S,6S)-6-Ethyl-3,5-dimethyltetrahydro-2H-pyran-2-on in diethyl ether T=-78°C; 0.0833333 h;
参考文献
Bioscience, Biotechnology and Biochemistry, , vol. 67, # 8 p. 1744 - 1750
反应条件
1: iPr2NH2, 2.5M n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -50 deg C, 10 min, then 0 deg C, 45 min 2: AcOH, 1M HCl / tetrahydrofuran; H2O / 48 h / 50 - 55 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 9 p. 2703 - 2714
反应条件
1: NaI, NaHCO3 / acetone / 24 h / Heating 2: iPr2NH2, 2.5M n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -50 deg C, 10 min, then 0 deg C, 45 min 3: AcOH, 1M HCl / tetrahydrofuran; H2O / 48 h / 50 - 55 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 9 p. 2703 - 2714
反应条件
1: pyridine / 0 °C / several hours 2: NaI, NaHCO3 / acetone / Heating; several hours 3: 1) LDA, / 1) THF-hexane-HMPA, -55 deg C, 30 min, 2) THF-hexane-HMPA, -60 to -5 deg C, 3 h 4: 37 percent / AcOH, H2O / tetrahydrofuran / 24 h / 40 °C View Scheme
参考文献
Tetrahedron, , vol. 41, # 16 p. 3423 - 3428
反应条件
1: 88 percent / LiAlH4 / diethyl ether / 5 h / 0 - 21 °C 2: 90 percent / Et3N, DMAP / CH2Cl2 / 18 h / Ambient temperature 3: imidazole / dimethylformamide / 24 h / Ambient temperature 4: NaI, NaHCO3 / acetone / 24 h / Heating 5: iPr2NH2, 2.5M n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -50 deg C, 10 min, then 0 deg C, 45 min 6: AcOH, 1M HCl / tetrahydrofuran; H2O / 48 h / 50 - 55 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 9 p. 2703 - 2714
反应条件
1: iPr2NH2, 2.5M n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -50 deg C, 10 min, then 0 deg C, 45 min 2: AcOH, 1M HCl / tetrahydrofuran; H2O / 48 h / 50 - 55 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 9 p. 2703 - 2714
反应条件
1: 90 percent / Et3N, DMAP / CH2Cl2 / 18 h / Ambient temperature 2: imidazole / dimethylformamide / 24 h / Ambient temperature 3: NaI, NaHCO3 / acetone / 24 h / Heating 4: iPr2NH2, 2.5M n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -50 deg C, 10 min, then 0 deg C, 45 min 5: AcOH, 1M HCl / tetrahydrofuran; H2O / 48 h / 50 - 55 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 9 p. 2703 - 2714
反应条件
1: imidazole / dimethylformamide / 24 h / Ambient temperature 2: NaI, NaHCO3 / acetone / 24 h / Heating 3: iPr2NH2, 2.5M n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -50 deg C, 10 min, then 0 deg C, 45 min 4: AcOH, 1M HCl / tetrahydrofuran; H2O / 48 h / 50 - 55 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 9 p. 2703 - 2714
反应条件
1: 76 percent / 30percent H2O2, LiOH / tetrahydrofuran; H2O / 2 h / 0 °C 2: 88 percent / LiAlH4 / diethyl ether / 5 h / 0 - 21 °C 3: 90 percent / Et3N, DMAP / CH2Cl2 / 18 h / Ambient temperature 4: imidazole / dimethylformamide / 24 h / Ambient temperature 5: NaI, NaHCO3 / acetone / 24 h / Heating 6: iPr2NH2, 2.5M n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -50 deg C, 10 min, then 0 deg C, 45 min 7: AcOH, 1M HCl / tetrahydrofuran; H2O / 48 h / 50 - 55 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 9 p. 2703 - 2714
反应条件
1: 43 percent / AcOH, H2O / tetrahydrofuran / 24 h / 40 °C 2: CDCl3 View Scheme
参考文献
Tetrahedron, , vol. 41, # 16 p. 3423 - 3428
