3-(哌啶-4-基)苄基氨基甲酸叔丁酯合成路线 （共 9 条）
反应条件
1: With hydrogenchloride in water
2: With sodium hydroxide in water
参考文献
Aventis Pharma Deutschland GmbH
Patent: EP1571150 A1, 2005 ;
Location in patent: Page/Page column 37 ;
反应条件
sodium hydroxide in water; toluene
T=20°C; 0.5 h;
参考文献
Aventis Pharma Deutschland GmbH
Patent: EP1571150 A1, 2005 ;
Location in patent: Page/Page column 38 ;
反应条件
1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethanol / 4 h / 2585.81 Torr
2: sodium hydrogencarbonate / dichloromethane / 20 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 50 °C
View Scheme
参考文献
SANOFI; CHOI-SLEDESKI, Yong Mi; LIANG, Guyan; NIEDUZAK, Thaddeus R.; POLI, Gregory B.; SHUM, Patrick Wai-Kwok; STOKLOSA, Gregory T.; ZHAO, Zhicheng
Patent: WO2011/79102 A1, 2011 ;
WO 2011/079102 A1
反应条件
1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / acetonitrile / 1.5 h / Reflux
2: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethanol / 4 h / 2585.81 Torr
3: sodium hydrogencarbonate / dichloromethane / 20 °C
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 50 °C
View Scheme
参考文献
SANOFI; CHOI-SLEDESKI, Yong Mi; LIANG, Guyan; NIEDUZAK, Thaddeus R.; POLI, Gregory B.; SHUM, Patrick Wai-Kwok; STOKLOSA, Gregory T.; ZHAO, Zhicheng
Patent: WO2011/79102 A1, 2011 ;
WO 2011/079102 A1
反应条件
1: sodium tetrahydroborate / NiII chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice
2: hydrogen / palladium-on-charcoal / methanol / 1 h
View Scheme
参考文献
CORNELL UNIVERSITY; COFERON, INC.; PURDUE RESEARCH FOUNDATION
Patent: US2012/295874 A1, 2012 ;
US 20120295874 A1
反应条件
1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / acetonitrile; water / 1 h / 90 °C
2: sodium tetrahydroborate / NiII chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice
3: hydrogen / palladium-on-charcoal / methanol / 1 h
View Scheme
参考文献
CORNELL UNIVERSITY; COFERON, INC.; PURDUE RESEARCH FOUNDATION
Patent: US2012/295874 A1, 2012 ;
US 20120295874 A1
反应条件
1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C
1.2: -78 - 20 °C
2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / acetonitrile; water / 1 h / 90 °C
3.1: sodium tetrahydroborate / NiII chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice
4.1: hydrogen / palladium-on-charcoal / methanol / 1 h
View Scheme
参考文献
CORNELL UNIVERSITY; COFERON, INC.; PURDUE RESEARCH FOUNDATION
Patent: US2012/295874 A1, 2012 ;
US 20120295874 A1
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere
1.2: 0 °C / Reflux
2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / acetonitrile; water / 1 h / 90 °C
3.1: sodium tetrahydroborate / NiII chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice
4.1: hydrogen / palladium-on-charcoal / methanol / 1 h
View Scheme
参考文献
CORNELL UNIVERSITY; COFERON, INC.; PURDUE RESEARCH FOUNDATION
Patent: US2012/295874 A1, 2012 ;
US 20120295874 A1
反应条件
1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / acetonitrile; water / 1 h / 90 °C
2: sodium tetrahydroborate / NiII chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice
3: hydrogen / palladium-on-charcoal / methanol / 1 h
View Scheme
参考文献
CORNELL UNIVERSITY; COFERON, INC.; PURDUE RESEARCH FOUNDATION
Patent: US2012/295874 A1, 2012 ;
US 20120295874 A1
