5-O-(4-甲基苯基磺酰基)胸腺嘧啶脱氧核苷合成路线 （共 15 条）
反应条件
1: 88 percent / NaN3 / dimethylformamide / 6 h / 80 °C
2: 6 h / Ambient temperature
3: H2O
View Scheme
参考文献
Nyilas, A.; Glemarec, C.; Chattopadhyaya, J.
Tetrahedron, 1990 , vol. 46, # 6 p. 2149 - 2164
反应条件
1: 94.5 percent / acetone / 6 h / 50 °C
2: aq. HCl / methanol / 2 h / 45 °C
View Scheme
参考文献
Jahn-Hofmann, Kerstin; Engels, Joachim W.
Helvetica Chimica Acta, 2004 , vol. 87, # 11 p. 2812 - 2828
参考文献
Elliot; Brockman; Montgomery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1052 - 1056
反应条件
1: acetone / 2 h / Heating
2: KOH / H2O; ethanol / 1 h / Ambient temperature
3: H2O; ethanol / 0.08 h / Ambient temperature
View Scheme
参考文献
Dereu; Zingaro
Bulletin des Societes Chimiques Belges, 1982 , vol. 91, # 8 p. 685 - 694
反应条件
1: 87 percent / pyridine / CH2Cl2 / Ambient temperature
2: lithium acetylide-ethylenediamine / dimethylsulfoxide / 2 h / Ambient temperature
View Scheme
参考文献
Crooks, Peter A.; Reynolds, Robert C.; Maddry, Joseph A.; Rathore, Anita; Akhtar, M. Shamim; et al.
Journal of Organic Chemistry, 1992 , vol. 57, # 10 p. 2830 - 2835
