3-氯-2-氟-5-(三氟甲基)吡啶合成路线 （共 16 条）
反应条件
potassium carbonate; cesium fluoride in dimethyl sulfoxide T=120°C; P=18.7519 - 22.5023 Torr; 4 h; Product distribution / selectivity;
参考文献
Pfleger, Christophe; Waldmeier, Pius; Wang, Shaoning
Patent: US2008/221327 A1, 2008 ;
Location in patent: Page/Page column 9-10 ;
反应条件
pyridine hydrogenfluoride; sodium nitrite 1.) O deg C, 20 min, 2.) 20 deg C, 1 h;
参考文献
Yoneda; Fukuhara
Tetrahedron, 1996 , vol. 52, # 1 p. 23 - 36
反应条件
ammonia in tetrahydrofuran T=35°C; P=1950.2 Torr; 28 h; AutoclaveInert atmosphere; Product distribution / selectivity;
参考文献
FINCHIMICA S.p.A.; PASTORIO, Andrea; MORA, Claudia
Patent: WO2011/92618 A1, 2011 ;
Location in patent: Page/Page column 9-11 ;
反应条件
indium; [N-butylthiazolium][Br] T=95°C; 14 h; Green chemistry;
参考文献
Molecules, , vol. 18, # 1 p. 398 - 407
反应条件
4-(N,N-dimethlyamino)pyridine in water; anhydrous propionitrile T=20°C; 5 h;
参考文献
US6699993 B1, ;
Page column 4 ;
反应条件
in dimethyl sulfoxide T=30°C; 0.833333 h;
参考文献
WO2005/47279 A1, ;
Page/Page column 56 ;
WO 2005/047279 A1
反应条件
potassium cyanide; Aliquatreg; 336 in water T=30°C; 5 h;
参考文献
EP1199305 A1, ;
Example 2 ;
反应条件
cesium fluoride in dimethyl sulfoxide
参考文献
The Dow Chemical Company
Patent: US4480102 A1, 1984 ;
反应条件
cesium fluoride in dimethyl sulfoxide
参考文献
The Dow Chemical Company
Patent: US4480102 A1, 1984 ;
反应条件
potassium carbonate; cesium fluoride in 1-methyl-pyrrolidin-2-one T=120°C; 16 h; Product distribution / selectivity;
参考文献
Pfleger, Christophe; Waldmeier, Pius; Wang, Shaoning
Patent: US2008/221327 A1, 2008 ;
Location in patent: Page/Page column 6 ;
