1-苄基-3-哌啶甲酸乙酯合成路线 （共 8 条）
反应条件
triethylamine in acetonitrile T=0 - 20°C; 2.5 h;
参考文献
Merck Sharp and Dohme Limited; DIRAT, Olivier; ELLIOTT, Jason, Matthew
Patent: WO2007/3965 A1, 2007 ;
Location in patent: Page/Page column 34 ;
WO 2007/003965 A1
反应条件
sodium carbonate in acetonitrile 15 h; Heating;
参考文献
Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532
反应条件
ammonium formate; palladium on activated charcoal in methanol 0.166667 h; Heating;
参考文献
Ram, Siya; Spicer, Leonard D.
Tetrahedron Letters, 1987 , vol. 28, # 5 p. 515 - 516
反应条件
sodium cyanide; ammonia T=55°C; 48 h;
参考文献
Jean, Ludovic; Baglin, Isabelle; Rouden, Jacques; Maddaluno, Jacques; Lasne, Marie-Claire
Tetrahedron Letters, 2001 , vol. 42, # 33 p. 5645 - 5649
反应条件
hydrazine hydrate in methanol 4 h; Heating;
参考文献
Jean, Ludovic; Baglin, Isabelle; Rouden, Jacques; Maddaluno, Jacques; Lasne, Marie-Claire
Tetrahedron Letters, 2001 , vol. 42, # 33 p. 5645 - 5649
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=5°C; 1 h; 2: With ethyl acetate in tetrahydrofuran
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/67401 A1, 2006 ;
Location in patent: Page/Page column 190-191 ;
WO 2006/067401 A1
反应条件
1: 95 percent / NH2NH2*H2O / methanol / 4 h / Heating 2: 80 percent / NaNO2; TFA / H2O / 2 h / 0 - 80 °C View Scheme
参考文献
Jean, Ludovic; Baglin, Isabelle; Rouden, Jacques; Maddaluno, Jacques; Lasne, Marie-Claire
Tetrahedron Letters, 2001 , vol. 42, # 33 p. 5645 - 5649
反应条件
sodium hydroxide in tetrahydrofuran; 1,4-dioxane; water T=20°C;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1403255 A1, 2004 ;
Location in patent: Page 66 ;
EP 1403255 A1
