3-苄基-7-噁-3-氮杂双环4.1.0庚烷合成路线 （共 8 条）
反应条件
1: With water; trifluoroacetic acid
T=20°C; 0.166667 h;
2: With N-chloro-succinimide in water
T=20 - 45°C;
3: With sodium hydroxide in water; toluene
T=12 - 40°C; 6 h;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: US2011/172431 A1, 2011 ;
Location in patent: Page/Page column 11-12 ;
反应条件
1.1: 25 h / 22 - 130 °C
2.1: sodium tetrahydroborate / ethanol / 20 h / 0 - 20 °C
3.1: trifluoroacetic acid / dichloromethane / 0 - 5 °C
3.2: 0.42 h / 0 - 6 °C
3.3: -15 - 10 °C
View Scheme
参考文献
Scheunemann, Matthias; Hennig, Lothar; Funke, Uta; Steinbach, Joerg
Tetrahedron, 2011 , vol. 67, # 19 p. 3448 - 3456
反应条件
1.1: 25 h / 22 - 130 °C
2.1: sodium tetrahydroborate / ethanol / 20 h / 0 - 20 °C
3.1: trifluoroacetic acid / dichloromethane / 0 - 5 °C
3.2: 0.42 h / 0 - 6 °C
3.3: -15 - 10 °C
View Scheme
参考文献
Scheunemann, Matthias; Hennig, Lothar; Funke, Uta; Steinbach, Joerg
Tetrahedron, 2011 , vol. 67, # 19 p. 3448 - 3456
反应条件
1.1: toluene / 1 h / 20 - 110 °C
1.2: 20.33 h / 20 °C
2.1: trifluoroacetic acid / toluene; water / 0.5 h / 20 - 28.2 °C
2.2: 14 h / 10 - 20 °C
2.3: 3 h / 4 - 20 °C
View Scheme
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: US2011/166357 A1, 2011 ;
反应条件
1.1: sodium tetrahydroborate / ethanol / 20 h / 0 - 20 °C
2.1: trifluoroacetic acid / dichloromethane / 0 - 5 °C
2.2: 0.42 h / 0 - 6 °C
2.3: -15 - 10 °C
View Scheme
参考文献
Scheunemann, Matthias; Hennig, Lothar; Funke, Uta; Steinbach, Joerg
Tetrahedron, 2011 , vol. 67, # 19 p. 3448 - 3456
反应条件
N-bromosuccinmide; trifluoroacetic acid in 1,4-dioxane; water
参考文献
Gijsen, Harrie J.M.; De Cleyn, Michel J.A.; Love, Christopher J.; Surkyn, Michel; Van Brandt, Sven F.A.; Verdonck, Marc G.C.; Moens, Luc; Cuypers, Jef; Bosmans, Jean-Paul R.M.A.
Tetrahedron, 2008 , vol. 64, # 10 p. 2456 - 2464
反应条件
1.1: methanol; sodium tetrahydroborate / 3 h / -5 - 20 °C
2.1: trifluoroacetic acid / water / 1 h / 20 °C
2.2: 35 °C
2.3: 20 °C
View Scheme
参考文献
BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; CAI, Xiongwei; CHAN, Timothy R.; CONLON, Patrick; HUMORA, Michael; JENKINS, Tracy J.; MACPHEE, J. Michael; SHI, Xianglin; MILLER, Ross A.; THOMPSON, Andrew
Patent: WO2013/185082 A2, 2013 ;
反应条件
dihydrogen peroxide; trifluoroacetic anhydride
参考文献
Samoshin, Andrey V.; Veselov, Ivan S.; Chertkov, Vyacheslav A.; Yaroslavov, Alexander A.; Grishina, Galina V.; Samoshina, Nataliya M.; Samoshin, Vyacheslav V.
Tetrahedron Letters, 2013 , vol. 54, # 41 p. 5600 - 5604
