4-(乙酰基氧基)-8-溴-5-甲氧基-2-萘羧酸乙酯合成路线 （共 3 条）
反应条件
sodium acetate
T=25 - 140°C; Inert atmosphere;
参考文献
Snyder, Scott A.; Sherwood, Trevor C.; Ross, Audrey G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 30 p. 5146 - 5150
反应条件
1: bromine; acetic acid / 36 h / 25 °C / Inert atmosphere
2: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 12 h / 25 °C / Inert atmosphere
3: trifluoroacetic acid; water / 1.5 h / 25 °C / Inert atmosphere
4: sodium acetate / 1 h / 140 °C / Inert atmosphere
View Scheme
参考文献
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; SNYDER, Scott Alan; SHERWOOD, Trevor C.; ROSS, Audrey G.; OH, Hyunju; GHOSH, Sankar
Patent: WO2011/103442 A2, 2011 ;
反应条件
1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 12 h / 25 °C / Inert atmosphere
2: trifluoroacetic acid; water / 1.5 h / 25 °C / Inert atmosphere
3: sodium acetate / 1 h / 140 °C / Inert atmosphere
View Scheme
参考文献
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; SNYDER, Scott Alan; SHERWOOD, Trevor C.; ROSS, Audrey G.; OH, Hyunju; GHOSH, Sankar
Patent: WO2011/103442 A2, 2011 ;
