2-氯-3-硝基-5-(三氟甲基)吡啶合成路线 （共 12 条）
反应条件
quinoline; trichlorophosphate 18 h; Heating / reflux;
参考文献
Respiratorius AB
Patent: WO2009/7418 A1, 2009 ;
Location in patent: Page/Page column 23 ;
反应条件
trichlorophosphate in acetonitrile 3 h; Heating;
参考文献
Ahn, Sung Oh; Park, Chan Hee; Im, Jun Hwan; Lee, Soon Ok; Lee, Kyoung June; Cho, Seong Wook; Ko, Kwang Seok; Han, Sun Young; Lee, Won Il
Patent: US2011/28467 A1, 2011 ;
Location in patent: Page/Page column 22 ;
US 20110028467 A1
参考文献
PFIZER INC.
Patent: EP436333 A2, 1991 ;
反应条件
1.1: nitric acid; sulfuric acid / water / 1 h / 80 °C 2.1: trichlorophosphate; quinoline / 5.5 h / Reflux 2.2: Cooling with ice View Scheme
反应条件
1: sulfuric acid; sodium nitrite / water / 0 - 20 °C / |Inert atmosphere 2: trichlorophosphate / N,N-dimethyl-formamide / 12 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Tetrahedron, , vol. 70, # 5 p. 1077 - 1083
反应条件
1: nitric acid; sulfuric acid / 0 - 20 °C / |Inert atmosphere 2: sulfuric acid; sodium nitrite / water / 0 - 20 °C / |Inert atmosphere 3: trichlorophosphate / N,N-dimethyl-formamide / 12 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Tetrahedron, , vol. 70, # 5 p. 1077 - 1083
反应条件
hydrazine hydrate in methanol T=80°C; 12 h;
参考文献
Chun, Kwangwoo; Park, Ji-Seon; Lee, Han-Chang; Kim, Young-Ha; Ye, In-Hea; Kim, Kang-Jeon; Ku, Il-Whea; Noh, Min-Young; Cho, Goang-Won; Kim, Heejaung; Kim, Seung Hyun; Kim, Jeongmin
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3983 - 3987
反应条件
tin(ll) chloride in ethyl acetate T=80°C; 2 h;
参考文献
BASF SE; BASF (CHINA) COMPANY LIMITED; METZ, Stefan; FUCHS, Evelyn; DORMANN, Korinna; MOLT, Oliver; LENNARTZ, Christian; WAGENBLAST, Gerhard; GEssNER, Thomas; SCHILDKNECHT, Christian; WATANABE, Soichi
Patent: WO2012/172482 A1, 2012 ;
Location in patent: Page/Page column 126 ;
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=3102.97 Torr; 16 h;
参考文献
WO2008/79965 A1, ;
Page/Page column 72-73 ;
反应条件
in 1-methyl-pyrrolidin-2-one
T=175°C; 0.25 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/97805 A1, 2005 ;
Location in patent: Page/Page column 62 ;
