1: With Mesityl-Li in tetrahydrofuran; pentane
Metallation; lithiation; 1 h;
2: With 1-[5'-toluenesulfonyl-2'-(methylamino)phenyl]-1,2,3,4-tetrahydroisoquinoline in tetrahydrofuran; pentane
T=-78 - -20°C; deracemization; Title compound not separated from byproducts;
参考文献
Vedejs; Kruger; Suna
Journal of Organic Chemistry, 1999 , vol. 64, # 21 p. 7863 - 7870
planar-chiral DMAP-ferrocene derivative; benzoic acid in toluene
48 h; Ambient temperaturemethanolysis of azlactones dynamic kinetic resolution of azlactones; enantiomeric excess; solvent effect on enantioselectivity; reaction with other alcohols; effect of steric factors on enantioselectivity; Product distribution;
参考文献
Liang, Jack; Ruble, Craig; Fu, Gregory C.
Journal of Organic Chemistry, 1998 , vol. 63, # 10 p. 3154 - 3155
tetraethylammonium bromide; copper(II) bis(trifluoromethanesulfonate); (-)-2,2′-isopropylidenebis[(4S)-4-phenyl-2-oxazoline]
T=20°C; Electrochemical reaction; Title compound not separated from byproducts.;
