6-(2-(三氟甲基)苯基)烟酸合成路线 (共 2 条)
反应条件
diisobutylaluminium hydride in hexane; toluene T=-78°C; 0.5 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/60882 A1, 2004 ;
Location in patent: Page 46-47 ;
WO 2004/060882 A1
反应条件
sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium(0) in ethanol; water; toluene
18 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2004/60882 A1, 2004 ;
Location in patent: Page 45-46 ;
WO 2004/060882 A1