甲基3-甲基-2-苯基丁酸酯合成路线 （共 5 条）
反应条件
sodium hydroxide in methanol; water
参考文献
Hoffmann-La Roche Inc.
Patent: US5250517 A1, 1993 ;
US 5250517 A
反应条件
sodium hydroxide in water 32 h; Ambient temperaturehorse liver esterase, pH 7.2; Yield given. Yields of byproduct given;
参考文献
Ahmar, M.; Girard, C.; Bloch, R.
Tetrahedron Letters, 1989 , vol. 30, # 50 p. 7053 - 7056
反应条件
sodium hydroxide in water 32 h; Ambient temperaturehorse liver esterase, pH 7.2; Yield given. Yields of byproduct given;
参考文献
Ahmar, M.; Girard, C.; Bloch, R.
Tetrahedron Letters, 1989 , vol. 30, # 50 p. 7053 - 7056
反应条件
1: 87 percent / LiAlH4 / diethyl ether
2: 91 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
View Scheme
参考文献
Adam, Waldemar; Bosio, Sara G.; Turro, Nicholas J.; Wolff, Barbara T.
Journal of Organic Chemistry, 2004 , vol. 69, # 5 p. 1704 - 1715
反应条件
1.1: 87 percent / LiAlH4 / diethyl ether
2.1: 91 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
3.1: 98 percent / p-TsOH / 12 h / Heating
4.1: 76 percent / O2; 5,10,15,20-tetrakis(pentafluorophenyl)porphine / CDCl3 / 6 h / -35 °C / Irradiation
5.1: L-methionine / acetonitrile; H2O / 0.25 h / 0 °C
5.2: 41 percent / NaBH4; DBU / tetrahydrofuran; H2O / 0.25 h / 0 °C
View Scheme
参考文献
Adam, Waldemar; Bosio, Sara G.; Turro, Nicholas J.; Wolff, Barbara T.
Journal of Organic Chemistry, 2004 , vol. 69, # 5 p. 1704 - 1715
