2,2-二甲基-5-异亚丙基-1,3-二噁烷-4,6-二酮合成路线 （共 13 条）
反应条件
1: potassium carbonate / N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 12 h / 50 - 55 °C 2: methanol / 12 h / Reflux 3: sodium hydroxide / Esterase V enzime / 24 h / pH ~ 10 / Sodium carbonate buffer; Resolution of racemate; Enzymatic reaction 4: isopropylmagnesium chloride / tetrahydrofuran / 30 - 35 °C / Inert atmosphere View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KOLLA, Naveen Kumar; APPAYE, Kaliyaperumal Srinivasan; GANGULA, Srinivas; GOVINDAPUR, Rajeshwar Reddy; MANNE, Nagaraju; NIKUMBH, Satish Pandurang; NEELAM, Uday Kumar; JOSEPH, Suju Chuttippari; BADDAM, Sudhakar Reddy; KUNHIMON, Shyam Kumar Unniaranpurakkal; MOOVENDAN, Mohan; DAHANUKAR, Vilas; DONIPARTHI, Kiran Kumar
Patent: WO2012/21446 A2, 2012 ;
反应条件
1: potassium carbonate / N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 12 h / 50 - 55 °C 2: methanol / 12 h / Reflux 3: sodium hydroxide / Esterase V enzime / 24 h / pH ~ 10 / Sodium carbonate buffer; Resolution of racemate; Enzymatic reaction View Scheme
反应条件
1: 91 percent / aq. HCl / 0.03 h / microwave irradiation 2: 84 percent / poly-4-vinylpyridine / dimethylformamide / 0.07 h / microwave irradiation View Scheme
参考文献
Helavi; Solabannavar; Desai; Mane
Journal of Chemical Research - Part S, 2003 , # 3 p. 174 - 175
反应条件
trifluoroacetic acid T=20°C; 0.25 h;
参考文献
Pohl; Hans; Hwan Young Lee; Yu Sam Kim; Cane; Khosla
Journal of the American Chemical Society, 2001 , vol. 123, # 24 p. 5822 - 5823
反应条件
formic acid; triethylamine in water; acetone
参考文献
BIOGAL GYOGYSZERGYAR
Patent: EP578849 A1, 1994 ;
参考文献
Hrubowchak, David M.; Smith, Francis X.
Tetrahedron Letters, 1983 , vol. 24, # 45 p. 4951 - 4954
反应条件
sulfuric acid in acetic anhydride
T=2°C;
参考文献
Kopinski, Richard P.; Pinhey, John T.; Rowe, Bruce A.
Australian Journal of Chemistry, 1984 , vol. 37, # 6 p. 1245 - 1254
反应条件
N-bromosuccinmide; polymer supported triphenyl phosphine; triethylamine
T=20°C; 1.5 h;
参考文献
Dhuru; Mohe; Salunkhe
Synthetic Communications, 2001 , vol. 31, # 23 p. 3653 - 3657
反应条件
sodium hydrogen telluride in ethanol
1.5 h; Heating;
参考文献
Huang, Xian; Xie, Linghong
Synthetic Communications, 1986 , vol. 16, # 13 p. 1701 - 1708
反应条件
copper(l) chloride in diethyl ether
T=-15 - 20°C; 1.25 h;
参考文献
Huang, Xian; Chan, Cheng-Chu; Wu, Quin-Li
Tetrahedron Letters, 1982 , vol. 23, p. 75 - 76
