1-(4-溴-1H-吡咯-2-基)-2,2,2-三氯-1-乙酮合成路线 （共 7 条）
反应条件
sodium hydroxide in tetrahydrofuran; water T=20°C; 1 h;
参考文献
ADDEX PHARMACEUTICALS SA
Patent: WO2006/123257 A2, 2006 ;
Location in patent: Page/Page column 63 ;
WO 2006/123257 A2
反应条件
sodium methylate 0.333333 h; Ambient temperature;
参考文献
Kitamura, Chitoshi; Yamashita, Yoshiro
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 10 p. 1443 - 1447
参考文献
BRISTOL-MYERS SQUIBB COMPANY; DEVASTHALE, Pratik; WASHBURN, William N.; RENDUCHINTALA, Kishore V.; SRIDHAR, Radhakrishnan
Patent: WO2010/42682 A1, 2010 ;
Location in patent: Page/Page column 50 ;
WO 2010/042682 A1
反应条件
in methanol T=0°C; 0.833333 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/72063 A1, 2004 ;
Location in patent: Page 29 ;
WO 2004/072063 A1
反应条件
1: With bromine; iodine in tetrachloromethane
T=0°C; 1 h;
2: With sodium hydrogencarbonate in tetrachloromethane; water
参考文献
Genelabs Technologies, Inc.
Patent: US2006/293320 A1, 2006 ;
Location in patent: Page/Page column 25; 34-35 ;
反应条件
bromine in chloroform
T=0°C; 4.5 h;
参考文献
Keifer, Paul A.; Schwartz, Robert E.; Koker, Moustapha E. S.; Hughes, Robert G.; Rittschof, Dan; Rinehart, Kenneth L.
Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 2965 - 2975
反应条件
bromine in chloroform
T=20°C; Cooling with ice;
参考文献
Clark, Benjamin R.; O'Connor, Stephen; Fox, Deirdre; Leroy, Jacques; Murphy, Cormac D.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 18 p. 6306 - 6311
