(+)-乙基 (R)-3-羟基-3-苯丙酸盐合成路线 （共 53 条）
反应条件
(S)-1-(PPh2)-2-[CH(OMe)(C6H4-o-PPh2)]-ferrocene; hydrogen; [Ru(cod)(C4H7)2]; hydrogen bromide in ethanol T=50°C; P=37503 Torr;
参考文献
Lotz, Matthias; Polborn, Kurt; Knochel, Paul
Angewandte Chemie - International Edition, 2002 , vol. 41, # 24 p. 4708 - 4711
反应条件
hydrogen; C50H44Cl2N2O8P4Ru(4-)*Zr(4+) in methanol T=20°C; P=72402.6 Torr; 20 h; Product distribution / selectivity;
参考文献
Lin, Wenbin; Hu, Aiguo; Ngo, Helen L.
Patent: US2004/192543 A1, 2004 ;
Location in patent: Page/Page column 9 ;
反应条件
Saccharomyces cerrvisatae (ATCC 9080) in water T=20°C; 48 h; Enzymatic reaction; Reagent/catalyst;
参考文献
Tetrahedron Asymmetry, , vol. 24, # 21-22 p. 1389 - 1394
反应条件
indium; CD 1.) THF, a) 0 deg C, 30 min, b) 18 deg C, 20 min, 2.) pentane, -75 to 18 deg C, 15 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 6 p. 711 - 714
反应条件
Candida rugose type VII lipase; water in di-isopropyl ether T=20°C; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 22, # 16-17 p. 1672 - 1679
反应条件
hydrogen; boric acid; nickel in methanol; water 4 h;
参考文献
Bernardi, Anna; Colombo, Lino; Gennari, Cesare; Prati, Laura
Tetrahedron, 1984 , vol. 40, # 19 p. 3769 - 3776
反应条件
6.5 h; Ambient temperaturephosphate buffer pH 7, lipase PS-30 from Pseudomonas sp.;
参考文献
Journal of Organic Chemistry, , vol. 57, # 15 p. 4289 - 4292
反应条件
1: chiral Ti(IV) complex / diethyl ether / 4 h / -10 °C 2: Bu4NF / tetrahydrofuran View Scheme
参考文献
Journal of the American Chemical Society, , vol. 116, # 19 p. 8837 - 8838
反应条件
N-((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)furan-2-carboxamide; diethylzinc in tetrahydrofuran; hexane T=0 - 20°C; Reformatsky Reaction; 1 h; Concentration; enantioselective reaction;
参考文献
Ananthi, Nallamuthu; Velmathi, Sivan
Journal of Chemical Sciences, 2014 , vol. 126, # 1 p. 151 - 158
反应条件
lt;C7H2(C2H5)2(C6H4)2C6H5gt;ClO4; hydrogen fluoride multistep reaction; other reagent, reaction time; Product distribution;
参考文献
Journal of the American Chemical Society, , vol. 119, # 46 p. 11341 - 11342
