(+)-乙基 (R)-3-羟基-3-苯丙酸盐合成路线 （共 53 条）
反应条件
1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C 2: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 8 p. 2169 - 2186
反应条件
Pseudomonas cepacia lipase immobilized on gold nanoparticles in aq. phosphate buffer T=23°C; 8 h; Resolution of racemateEnzymatic reaction; Catalytic behavior; Reagent/catalystTime;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 90, p. 12 - 16
反应条件
vinyl acetate; subtilisin in di-isopropyl ether T=10 - 40°C; resolution; Thermodynamic data;
参考文献
Chemistry Letters, , # 7 p. 782 - 783
反应条件
magnesium chloride; Candida rugosa lipase in di-isopropyl ether; water T=30°C; 24 h; Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 61, # 8 p. 2169 - 2186
反应条件
1: With dihydrogen peroxide in chloroform T=-20°C; 16 h; 2: With N-ethyl-N,N-diisopropylamine in chloroform T=30°C; 15 h; Further stages. Title compound not separated from byproducts.;
参考文献
Tetrahedron Letters, , vol. 48, # 34 p. 5976 - 5980
参考文献
Journal of the American Chemical Society, , vol. 83, p. 4228 - 4233
反应条件
Candida rugose type VII lipase; water in di-isopropyl ether T=20°C; 15 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 22, # 16-17 p. 1672 - 1679
反应条件
in ethanol T=0°C; transesterification; 20 h; Title compound not separated from byproducts.;
参考文献
Journal of Organic Chemistry, , vol. 65, # 6 p. 1702 - 1706
反应条件
1: DMSO/oxalyl chloride / CH2Cl2 / 2 h / -60 °C 2: piperidinium acetate / benzene / 2 h / Heating View Scheme
参考文献
Synthesis, , p. 305 - 311
反应条件
Candida rugose type VII lipase in octane T=20°C; 15 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 22, # 16-17 p. 1672 - 1679
