(+)-乙基 (R)-3-羟基-3-苯丙酸盐合成路线 （共 53 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 1 h;
参考文献
Xu, Chengfu; Yuan, Chengye
Tetrahedron, 2005 , vol. 61, # 8 p. 2169 - 2186
反应条件
1: immobilised Candida parapsilosis ATCC 7330 whole cells / H2O; ethanol / 25 °C
2: sodium borohydride
View Scheme
参考文献
Padhi, Santosh Kumar; Titu; Pandian, N. Ganesh; Chadha, Anju
Tetrahedron, 2006 , vol. 62, # 21 p. 5133 - 5140
反应条件
1: 93 percent / imidazole / CH2Cl2
2: 82 percent / Me3Al / CH2Cl2
3: 85 percent / n-BuLi / diethyl ether / -78 - 20 °C
4: 83 percent / p-TsOH / tetrahydrofuran; H2O / 55 °C
5: 5 percent / PPh3; DEAD / tetrahydrofuran / 0 °C
View Scheme
参考文献
Hodgetts, Kevin J.
Tetrahedron Letters, 2001 , vol. 42, # 22 p. 3763 - 3766
