1: propionic acid tert-butyl ester With n-butyllithium; diisopropylamine in cyclohexane; CPME T=0°C; 0.833333 h; Inert atmosphere; 2: chloro-trimethyl-silane in cyclohexane; CPME T=0°C; 2.25 h; Inert atmosphere; optical yield given as percent de;

1: propionic acid tert-butyl ester With n-butyllithium; diisopropylamine in hexane T=0 - 5°C; 0.75 h; 2: chloro-trimethyl-silane in hexane T=0 - 5°C; 1.58333 h; Further stages.;

lithium diisopropyl amide 1) THF, hexane, -70 deg C, 20 min; 2) -70 deg C to room temp., 0.5-1.0 h; Multistep reaction. Title compound not separated from byproducts;