(S)-(-)-3-苯甲酰巯基-2-甲基丙酸合成路线 （共 4 条）
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 31, # 2 p. 570 - 576
JAOCS, Journal of the American Oil Chemists' Society, , vol. 73, # 11 p. 1363 - 1375
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 9 p. 3139 - 3146
反应条件
1: trans-4-phenylthio-L-proline, hydrochloride With triethylamine in toluene T=25 - 30°C; 1 h; 2: (2S)-3-(benzoylthio)-2-methylpropionic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide in toluene T=30 - 35°C;
参考文献
GLENMARK GENERICS LIMITED; AHMED KHAN, Mubeen; SINGH YADAV, Roop; RASIKLAL TRIVEDI, Nikhil; MAHADEO LAD, Sachin
Patent: WO2010/84515 A2, 2010 ;
Location in patent: Page/Page column 31 ;
反应条件
sodium hydroxide; N,N-dimethyl-formamide in dichloromethane; 2-methylpropyl acetate
参考文献
MENARI RICERCHE S.P.A.
Patent: US2002/156293 A1, 2002 ;
