SUC-ALA-ALA-PRO-VAL-PNA合成路线 （共 7 条）
反应条件
Bacillus subtilis subtilisin A pH=7.3; aq. phosphate bufferEnzymatic reaction;
参考文献
Daniel, Roy M.; Peterson, Michelle E.; Danson, Michael J.; Price, Nicholas C.; Kelly, Sharon M.; Monk, Colin R.; Weinberg, Cristina S.; Oudshoorn, Matthew L.; Lee, Charles K.
Biochemical Journal, 2010 , vol. 425, # 2 p. 353 - 360
反应条件
in acetonitrile
24 h;
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
1: 71 percent / 24 h / Ambient temperature
2: 69 percent / 1N NaOH / dioxane / 24 h / Ambient temperature
3: 73 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / 1 h / -15 - 20 °C
4: HBr / trifluoroacetic acid
5: 70 percent / acetonitrile / 24 h
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
1: 69 percent / 1N NaOH / dioxane / 24 h / Ambient temperature
2: 73 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / 1 h / -15 - 20 °C
3: HBr / trifluoroacetic acid
4: 70 percent / acetonitrile / 24 h
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
1: HBr / trifluoroacetic acid
2: 70 percent / acetonitrile / 24 h
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
1: 73 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / 1 h / -15 - 20 °C
2: HBr / trifluoroacetic acid
3: 70 percent / acetonitrile / 24 h
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
in methanol; diethyl ether
0.0833333 h; Ambient temperature;
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
