2-丁基-2H-1,4-苯并噻嗪-3(4h)-酮合成路线 （共 4 条）
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide
T=20°C; 1 h;
2: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide
T=20°C; 1.5 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/11190 A1, 2008 ;
Location in patent: Page/Page column 50 ;
WO 2008/011190 A1
反应条件
1-methyl-piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene
T=180°C; P=7757.22 Torr; 4 h; microwave irradiation;
参考文献
Kamila, Sukanta; Koh, Benjamin; Khan, Omair; Zhang, Hongming; Biehl, Edward R.
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1641 - 1646
反应条件
in N,N-dimethyl-formamide
T=90 - 95°C; 0.25 h;
参考文献
Tawada; Sugiyama; Ikeda; Yamamoto; Meguro
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 5 p. 1238 - 1245
反应条件
potassium carbonate in diethyl ether
参考文献
Hori; Kataoka; Shimizu; Imai
Chemical and Pharmaceutical Bulletin, 1979 , vol. 27, # 9 p. 1973 - 1981
