4-氯-6,7-亚甲基二氧基喹唑啉合成路线 （共 8 条）
反应条件
trichlorophosphate Reflux;
参考文献
Garofalo, Antonio; Goossens, Laurence; Baldeyrou, Brigitte; Lemoine, Amelie; Ravez, Severine; Six, Perrine; David-Cordonnier, Marie-Helene; Bonte, Jean-Paul; Depreux, Patrick; Lansiaux, Amelie; Goossens, Jean-Francois
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 8089 - 8103
反应条件
1: thionyl chloride / Reflux 2: nitric acid; tin(IV) chloride / dichloromethane / -70 °C 3: hydrogen / methanol / 20 °C 4: sodium methylate / methanol; N,N-dimethyl-formamide / 110 °C 5: trichlorophosphate / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 22 p. 8089 - 8103
反应条件
1: sodium methylate / methanol; N,N-dimethyl-formamide / 110 °C 2: trichlorophosphate / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 22 p. 8089 - 8103
反应条件
1: nitric acid; tin(IV) chloride / dichloromethane / -70 °C 2: hydrogen / methanol / 20 °C 3: sodium methylate / methanol; N,N-dimethyl-formamide / 110 °C 4: trichlorophosphate / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 22 p. 8089 - 8103
反应条件
1: hydrogen / methanol / 20 °C 2: sodium methylate / methanol; N,N-dimethyl-formamide / 110 °C 3: trichlorophosphate / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 22 p. 8089 - 8103
反应条件
1.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C 2.1: trifluoroacetic acid / 0.17 h / 110 °C / |Microwave irradiation 2.2: 4 h / |Reflux 3.1: acetic acid; ammonium cerium (IV) nitrate / water / 0.08 h / 20 °C 4.1: triethylamine; trichlorophosphate / 3 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 67, p. 373 - 383
反应条件
1.1: trifluoroacetic acid / 0.17 h / 110 °C / |Microwave irradiation 1.2: 4 h / |Reflux 2.1: acetic acid; ammonium cerium (IV) nitrate / water / 0.08 h / 20 °C 3.1: triethylamine; trichlorophosphate / 3 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 67, p. 373 - 383
反应条件
1: acetic acid; ammonium cerium (IV) nitrate / water / 0.08 h / 20 °C 2: triethylamine; trichlorophosphate / 3 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 67, p. 373 - 383
