反应条件
1: ethyl 1,2-dihydro-1-oxophthalazin-4-ylacetate With sodium hydroxide in tetrahydrofuran
T=40 - 50°C; 0.5 h;
2: 1-bromo-4-bromomethyl-3-fluorobenzene in tetrahydrofuran
T=50 - 60°C; 2 h;
3: With acetic acid in tetrahydrofuran; water
pH=2 - 3;
参考文献
Sriram, Dharmarajan; Yogeeswari, Perumal; Senthilkumar, Palaniappan; Sangaraju, Dewakar; Nelli, Rohit; Banerjee, Debjani; Bhat, Pritesh; Manjashetty, Thimmappa H.
Chemical Biology and Drug Design, 2010 , vol. 75, # 4 p. 381 - 391