甲基(E)-3-[4-羟基-3-(3-甲基丁-2-烯基)苯基]丙-2-烯酸酯合成路线 （共 16 条）
反应条件
1: 96 percent / (o-tol)3P, Et3N / Pd(OAc)2 / toluene / 20 h / Heating
2: 89 percent / K2CO3 / methanol
View Scheme
参考文献
Bates; Gabel
Tetrahedron Letters, 1993 , vol. 34, # 22 p. 3547 - 3550
反应条件
1: 63 percent / H2SO4 / Heating
2: 1.) NaH / 1.) toluene, 60 - 65 deg C, 3.5 h, 2.) 35 deg C, 72 h.
View Scheme
参考文献
Menon, Sanjay R.; Patel, Vishal K.; Mitscher, Lester A.; Shih, Peter; Pillai, Segaran P.; Shankel, Delbert M.
Journal of Natural Products, 1999 , vol. 62, # 1 p. 102 - 106
反应条件
sodium hydride
1.) toluene, 60 - 65 deg C, 3.5 h, 2.) 35 deg C, 72 h.; Yield given. Multistep reaction;
参考文献
Menon, Sanjay R.; Patel, Vishal K.; Mitscher, Lester A.; Shih, Peter; Pillai, Segaran P.; Shankel, Delbert M.
Journal of Natural Products, 1999 , vol. 62, # 1 p. 102 - 106
反应条件
sodium hydroxide
1.) water, 22 degC, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kitagawa; Fukuda; Yoshihara; Yamahara; Yoshikawa
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 1 p. 352 - 355
反应条件
sodium hydroxide in water
2.5 h; Heating;
参考文献
Menon, Sanjay R.; Patel, Vishal K.; Mitscher, Lester A.; Shih, Peter; Pillai, Segaran P.; Shankel, Delbert M.
Journal of Natural Products, 1999 , vol. 62, # 1 p. 102 - 106
反应条件
sodium hydroxide in water
2.5 h; Heating;
参考文献
Menon, Sanjay R.; Patel, Vishal K.; Mitscher, Lester A.; Shih, Peter; Pillai, Segaran P.; Shankel, Delbert M.
Journal of Natural Products, 1999 , vol. 62, # 1 p. 102 - 106
