4-氰基-2-甲氧基吡啶合成路线 （共 14 条）
反应条件
in 1,4-dioxane; methanol 5 h; Reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/9889 A1, 2006 ;
Location in patent: Page/Page column 54 ;
WO 2006/009889 A1
反应条件
sodium in methanol; methanoldioxan; water
参考文献
Smith Kline and French Laboratories Limited
Patent: US4234588 A1, 1980 ;
反应条件
sodium in 1,4-dioxane T=10°C;
参考文献
WO2006/12374 A1, ;
Page/Page column 150 ;
WO 2006/012374 A1
反应条件
in tetrahydrofuran; methanol 6 h; Heating / reflux;
参考文献
EP1424336 A1, ;
Page 56 ;
反应条件
water Diazotization;
参考文献
Roczniki Chemii, , vol. 33, p. 1343,1345
Chem.Abstr., , p. 13123
反应条件
1: TBME / tetrahydrofuran / 4.5 h / 0 °C 2: 62 percent / H2SO4; para-toluenesulfonic acid monohydrate / toluene / 72 h / Heating View Scheme
参考文献
Peters, Rene; Althaus, Martin; Diolez, Christian; Rolland, Alain; Manginot, Eric; Veyrat, Marc
Journal of Organic Chemistry, 2006 , vol. 71, # 20 p. 7583 - 7595
反应条件
formaldehyd; sodium acetate; nickel monoaluminide in hydrogenchloride; ethanol; water
参考文献
Smith Kline and French Laboratories Limited
Patent: US4234588 A1, 1980 ;
反应条件
hydrogenchloride; formaldehyd; hydrogen; semicarbazide-hydrochloride; sodium acetate; nickel 1.) EtOH, H2O, 50 psi, 2.) EtOH, H2O, heating, 30 min; Yield given. Multistep reaction;
参考文献
Brown, T. H.; Blakemore, R. C.; Durant, G. J.; Ganellin, C. R.; Parsons, M. E.; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 7-8 p. 601 - 608
反应条件
ammonia; hydrogen; nickel in methanol P=3800 Torr; 1.25 h;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 16 p. 2362 - 2372
参考文献
Talik; Plazek
Roczniki Chemii, 1959 , vol. 33, p. 1343,1345
Chem.Abstr., 1960 , p. 13123
