4-氰基-2-甲氧基吡啶合成路线 （共 14 条）
反应条件
1: pyridine / dichloromethane / 20 h / 20 °C
2: dimethylsulfoxide-d6 / 25 °C
View Scheme
参考文献
Topczewski, Joseph J.; Quinn, Daniel M.
Organic Letters, 2013 , vol. 15, # 5 p. 1084 - 1087
反应条件
in tetrahydrofuran; diethyl ether
T=-78 - 25°C; Inert atmosphere;
参考文献
Chowdhury, Morshed Alam; Abdellatif, Khaled R.A.; Dong, Ying; Das, Dipankar; Suresh, Mavanur R.; Knaus, Edward E.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6138 - 6141
反应条件
1: in tetrahydrofuran; tert-butyl methyl ether
T=0°C; 8.92 h;
2: With water in tetrahydrofuran; tert-butyl methyl ether
T=0 - 20°C; 16 h;
参考文献
SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUE (S.C.R.A.S.)
Patent: WO2006/33011 A1, 2006 ;
Location in patent: Page/Page column 29 ;
反应条件
1: 1.) H2, semicarbazide hydrochloride, NaOAc, 2.) 10percent aq. HCl, 36percent aq. CH2O / 1.) Raney Ni / 1.) EtOH, H2O, 50 psi, 2.) EtOH, H2O, heating, 30 min
2: pyridine, piperidine / Heating
3: H2 / 5percent Pd/C / ethanol
View Scheme
参考文献
Brown, T. H.; Blakemore, R. C.; Durant, G. J.; Ganellin, C. R.; Parsons, M. E.; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 7-8 p. 601 - 608
