5-[(6-甲基-3-吡啶基)甲基]-2-(硝基氨基)-4(1H)-嘧啶酮合成路线 （共 10 条）
反应条件
sodium methylate; sodium in methanol; water
参考文献
Smith Kline and French Laboratories Limited
Patent: US4227000 A1, 1980 ;
反应条件
1: pyridine, piperidine
2: conc. H2SO4
3: H2 / 5percent Pd/C / ethanol / 45 °C
4: NaH / 1,2-dimethoxy-ethane / 20 h / Ambient temperature
5: sodium methoxide / methanol / 18 h / Heating
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1: conc. H2SO4
2: H2 / 5percent Pd/C / ethanol / 45 °C
3: NaH / 1,2-dimethoxy-ethane / 20 h / Ambient temperature
4: sodium methoxide / methanol / 18 h / Heating
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1: H2 / 5percent Pd/C / ethanol / 45 °C
2: NaH / 1,2-dimethoxy-ethane / 20 h / Ambient temperature
3: sodium methoxide / methanol / 18 h / Heating
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
in ethylene glycol dimethyl ether
参考文献
Smith Kline and French Laboratories Limited
Patent: US4305945 A1, 1981 ;
US 4305945 A
反应条件
1: NaH / 1,2-dimethoxy-ethane / 20 h / Ambient temperature
2: sodium methoxide / methanol / 18 h / Heating
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
in ethanol
24 h; Heating;
参考文献
Brown; Armitage; Blakemore; Blurton; Durant; Ganellin; Ife; Parsons; Rawlings; Slingsby
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 3 p. 217 - 226
反应条件
hydrogenchloride in ethanol
24 h; Heating;
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1: 83 percent / ethanol / 24 h / Heating
2: H2O; acetic acid / Heating
View Scheme
参考文献
Brown; Armitage; Blakemore; Blurton; Durant; Ganellin; Ife; Parsons; Rawlings; Slingsby
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 3 p. 217 - 226
反应条件
in ethanol
24 h; Heating;
参考文献
Brown; Armitage; Blakemore; Blurton; Durant; Ganellin; Ife; Parsons; Rawlings; Slingsby
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 3 p. 217 - 226
