3-甲基-4-氧-4,5,6,7-四氢-1氢-吲哚-2-甲酸乙酯合成路线 （共 10 条）
反应条件
1: With sodium hydroxide in ethanol 1 h; Reflux; 2: With hydrogenchloride in water
参考文献
Barraja, Paola; Diana, Patrizia; Montalbano, Alessandra; Carbone, Anna; Cirrincione, Girolamo; Viola, Giampietro; Salvador, Alessia; Vedaldi, Daniela; Dall'Acqua, Francesco
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 22 p. 9668 - 9683
反应条件
1: ethyl acetoacetate With acetic acid; sodium nitrite
3 h;
2: 1,3-cylohexanedione With sodium acetate; zinc in acetic acid
Knorr pyrrole synthesis; 1 h;
参考文献
Elliott, Luke D.; Berry, Malcolm; Orr-Ewing, Andrew J.; Booker-Milburn, Kevin I.
Journal of the American Chemical Society, 2007 , vol. 129, # 11 p. 3078 - 3079
反应条件
sodium acetate; acetic acid; zinc in water
Knorr pyrrole synthesis; Reflux;
参考文献
Barraja, Paola; Diana, Patrizia; Montalbano, Alessandra; Carbone, Anna; Cirrincione, Girolamo; Viola, Giampietro; Salvador, Alessia; Vedaldi, Daniela; Dall'Acqua, Francesco
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 22 p. 9668 - 9683
反应条件
sodium acetate; zinc in acetic acid
Heating;
参考文献
Elghamry, Ibrahim
Synthetic Communications, 2002 , vol. 32, # 6 p. 897 - 902
反应条件
sodium acetate; acetic acid; zinc
1 h; Heating;
参考文献
Lash, Timothy D.; Bladel, Karla A.; Shiner, Craig M.; Zajeski, Donna L.; Balasubramaniam, Rajiv P.
Journal of Organic Chemistry, 1992 , vol. 57, # 18 p. 4809 - 4820
反应条件
in diethyl ether
0.333333 h; Irradiation; Yields of byproduct given;
参考文献
Gelas-Mialhe, Yvonne; Mabiala, Gaston; Vessiere, Roger
Journal of Organic Chemistry, 1987 , vol. 52, # 24 p. 5395 - 5400
反应条件
sodium hydroxide in ethanol; water
3 h; Heating;
参考文献
Clezy, Peter S.; Prashar, Jognandan K.
Australian Journal of Chemistry, 1990 , vol. 43, # 5 p. 825 - 837
反应条件
1: 1) NaH / 1) benzene, reflux, 2 h, 2a) RT, overnight, 2b) benzene, reflux, 6 h
2: 58.6 percent / NaH / benzene / 4 h / Heating
View Scheme
参考文献
Singh, Rajeshwar; Bhagavateeswaran, H.; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 9 p. 853 - 856
反应条件
1: 1) NaH / 1) benzene, reflux, 2 h, 2a) RT, overnight, 2b) benzene, reflux, 6 h
2: 58.6 percent / NaH / benzene / 4 h / Heating
3: 39.7 percent / sodium ethoxide / ethanol / 4 h / Heating
View Scheme
参考文献
Singh, Rajeshwar; Bhagavateeswaran, H.; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 9 p. 853 - 856
反应条件
1: 1) NaH / 1) benzene, reflux, 2 h, 2a) RT, overnight, 2b) benzene, reflux, 6 h
2: 80 percent / phenyltrimethylammonium perbromide / tetrahydrofuran / 24 h
3: 53.4 percent / triethylamine / methanol / 18 h / Heating
View Scheme
参考文献
Singh, Rajeshwar; Bhagavateeswaran, H.; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 9 p. 853 - 856
