4-羟基甲基-3-吡啶羧酸合成路线 （共 5 条）
反应条件
sodium tetrahydroborate in N,N-dimethyl-formamide; toluene T=-20 - 35°C; 1.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2726 - 2735
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Journal of Organic Chemistry, , vol. 45, # 6 p. 1176
反应条件
1: sodium hydroxide, water / 1.5 h / 20 °C 2: 5.1 g / lithium aluminium hydride / tetrahydrofuran / 0.07 h / 0 - 2 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 3012 - 3015
反应条件
phosphorus pentachloride in dichloromethane
参考文献
Bottaro, Jeffrey C.; Berchtold, Glenn A.
Journal of Organic Chemistry, 1980 , vol. 45, # 6 p. 1176
反应条件
hydrogenchloride
0.5 h; Heating; Yield given;
参考文献
Orlek, Barry S.; Blaney, Frank E.; Brown, Frank; Clark, Michael S. G.; Hadley, Michael S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2726 - 2735
