1-羟基-5-甲氧基-6-甲基吡啶-2-酮合成路线 (共 10 条)
反应条件
sodium hydroxide
T=150°C; P=9000.72 Torr; 0.333333 h; microwave irradiation;
参考文献
Klumpp, Cedric; Burger, Alain; Mislin, Gaetan L.; Abdallah, Mohamed A.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 6 p. 1721 - 1724
反应条件
potassium hydroxide; potassium carbonate in toluene; benzyl alcohol
2 h; Heating;
参考文献
Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko
Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884
反应条件
1: 22 percent / Br2; aq. NaOH / 20 °C
2: 91 percent / methanol; CH2Cl2 / 20 °C
3: 84 percent / mCPBA / CHCl3 / 18 h / Heating
4: aq. NaOH / 0.33 h / 150 °C / 9000.72 Torr / microwave irradiation
View Scheme
参考文献
Klumpp, Cedric; Burger, Alain; Mislin, Gaetan L.; Abdallah, Mohamed A.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 6 p. 1721 - 1724
反应条件
1: 91 percent / methanol; CH2Cl2 / 20 °C
2: 84 percent / mCPBA / CHCl3 / 18 h / Heating
3: aq. NaOH / 0.33 h / 150 °C / 9000.72 Torr / microwave irradiation
View Scheme
参考文献
Klumpp, Cedric; Burger, Alain; Mislin, Gaetan L.; Abdallah, Mohamed A.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 6 p. 1721 - 1724
反应条件
1: 84 percent / mCPBA / CHCl3 / 18 h / Heating
2: aq. NaOH / 0.33 h / 150 °C / 9000.72 Torr / microwave irradiation
View Scheme
参考文献
Klumpp, Cedric; Burger, Alain; Mislin, Gaetan L.; Abdallah, Mohamed A.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 6 p. 1721 - 1724
反应条件
1: 90 percent / NaBO3 / acetic acid / 5.5 h / 80 °C
2: 40 percent / concd. H2SO4, f. HNO3 / 2 h / Heating
3: 34 percent / AcCl / 0.33 h / Ambient temperature
4: 34 percent / KOH, K2CO3, TDA-1 / toluene; phenylmethanol / 2 h / Heating
View Scheme
参考文献
Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko
Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884
反应条件
1: 90 percent / Pd(PPh3)4 / dioxane; hexane / 5.5 h / Heating
2: 90 percent / NaBO3 / acetic acid / 5.5 h / 80 °C
3: 40 percent / concd. H2SO4, f. HNO3 / 2 h / Heating
4: 34 percent / AcCl / 0.33 h / Ambient temperature
5: 34 percent / KOH, K2CO3, TDA-1 / toluene; phenylmethanol / 2 h / Heating
View Scheme
参考文献
Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko
Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884
反应条件
1: 90 percent / POCl3, PCl5 / 1 h / 140 °C
2: 90 percent / Pd(PPh3)4 / dioxane; hexane / 5.5 h / Heating
3: 90 percent / NaBO3 / acetic acid / 5.5 h / 80 °C
4: 40 percent / concd. H2SO4, f. HNO3 / 2 h / Heating
5: 34 percent / AcCl / 0.33 h / Ambient temperature
6: 34 percent / KOH, K2CO3, TDA-1 / toluene; phenylmethanol / 2 h / Heating
View Scheme
参考文献
Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko
Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884
反应条件
1: 40 percent / concd. H2SO4, f. HNO3 / 2 h / Heating
2: 34 percent / AcCl / 0.33 h / Ambient temperature
3: 34 percent / KOH, K2CO3, TDA-1 / toluene; phenylmethanol / 2 h / Heating
View Scheme
参考文献
Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko
Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884
反应条件
1: 34 percent / AcCl / 0.33 h / Ambient temperature
2: 34 percent / KOH, K2CO3, TDA-1 / toluene; phenylmethanol / 2 h / Heating
View Scheme
参考文献
Ohta, Akihiro; Takahashi, Nobuhiro; Shirokoma, Yasuko
Heterocycles, 1990 , vol. 30, # 2 p. 875 - 884