2-溴-6-(氯甲基)吡啶合成路线 （共 4 条）
反应条件
1: With thionyl chloride in chloroform
T=20°C; 3 h;
2: With sodium hydrogencarbonate in chloroform; water
参考文献
JAPAN TOBACCO INC.
Patent: US2006/205731 A1, 2006 ;
Location in patent: Page/Page column 52 ;
US 20060205731 A1
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2004/14902 A2, 2004 ;
Location in patent: Page 62 ;
WO 2004/014902 A2
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 5 h
2.1: acetic anhydride / 12 h / 90 °C
2.2: 0 - 20 °C
3.1: thionyl chloride / dichloromethane / 0 - 20 °C
View Scheme
参考文献
Deng, Lisheng; Diao, Jiasheng; Chen, Pinhong; Pujari, Venugopal; Yao, Yuan; Cheng, Gang; Crick, Dean C.; Prasad, B. V. Venkataram; Song, Yongcheng
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4721 - 4734
反应条件
1.1: acetic anhydride / 12 h / 90 °C
1.2: 0 - 20 °C
2.1: thionyl chloride / dichloromethane / 0 - 20 °C
View Scheme
参考文献
Deng, Lisheng; Diao, Jiasheng; Chen, Pinhong; Pujari, Venugopal; Yao, Yuan; Cheng, Gang; Crick, Dean C.; Prasad, B. V. Venkataram; Song, Yongcheng
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4721 - 4734
