hydrogenchloride; (S)-1-phenyl-ethylamine; hydrogen; palladium dichloride 1.) DME, 20 deg C, 5 h; Product distribution;

copper carbonate hydroxide; sodium hydroxide 1.) H2O, reflux, 2.5 h, 2.) RT, overnight; Yield given. Multistep reaction;

(i) CuCO3*Cu(OH)2, (ii) aq. NaOH, NaHCO3, dioxane; Multistep reaction;

hexa-methyldisilazane in toluene 168 h; Heating / reflux;

1.1: aq. LiOH / 0 °C 2.1: aq. NaOH / ethanol / 0.33 h / -10 - 20 °C 2.2: HCl / ethanol / 0.17 h / 50 °C View Scheme

Yield given. Multistep reaction;

1: 1.) basic copper carbonate, 2.) NaOH / 1.) H2O, reflux, 2.5 h, 2.) RT, overnight 2: 91 percent / aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature 3: H2 / 5percent Pd/C / methanol; H2O / 24 h / 2585.7 Torr View Scheme

1: 1.) basic copper carbonate, 2.) NaOH / 1.) H2O, reflux, 2.5 h, 2.) RT, overnight 2: 91 percent / aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature 3: H2 / 5percent Pd/C / methanol; H2O / 24 h / 2585.7 Torr 4: dimethylformamide / 120 h / Ambient temperature View Scheme